Diabetes may be affected by many nutritional deficiencies, and use of diabetic medications may increase the body’s nutritional needs. Glipizide may cause an additional depletion of nutrients, especially vitamin B-12. It may be important to supplement the diet with a multivitamin containing this nutrient.
• Glipizide may also deplete co-enzyme Q10 with long term use of the drug. Discuss supplementation with a pharmacist or physician before initiating supplement use because Co-Q10 may also reduce blood sugar levels. Monitor sugar levels.
• High doses of the vitamin niacin may increase blood glucose levels, and excessive use of this nutrient should be avoided.
• Alcohol use should be limited, as it can interfere with diabetes management.
• Use magnesium and vitamin E supplements with caution with glipizide because the supplements may increase the drugs’ effects.
• Avoid L-carnitine and chromium with glipizide due to possible additive hypoglycemic effects.
• Potatoes can interfere with blood sugar levels and glipizide dosage may require adjustment.
• The following herbs may lower blood sugar levels: Alfalfa, Aloe vera, Bilberry, Burdock, Bitter Melon, Celery, Cornsilk, Eucalyptus, Fenugreek, Garlic, Gymnema, Panax Ginseng, Marshmallow, Myrrh, Nettle, Onions, Sage and Tansy.
• Due to the known interaction between salicylates and this medication, it would be advisable to avoid herbs with salicylate properties with this drug: meadowsweet, poplar and white willow.
Glipizide Side effects:
- easy bruising or bleeding (nosebleeds, bleeding gums), feeling tired or short of breath, rapid heart rate;
- pale or yellowed skin, dark colored urine, fever, confusion; or
- throbbing headache, severe nausea and vomiting, fast or pounding heartbeats, sweating or thirst, feeling like you might pass out.
Less serious side effects may include:
- nausea, stomach pain;
- diarrhea, constipation;
- dizziness, drowsiness; or
- skin rash, redness, or itching.